MULTISYSTEMIC MANIFESTATIONS IN A COHORT OF 75 CLASSICAL EHLERS-DANLOS SYNDROME PATIENTS: NATURAL HISTORY AND NOSOLOGICAL PERSPECTIVES

Multisystemic manifestations in a cohort of 75 classical Ehlers-Danlos syndrome patients: natural history and nosological perspectives

Abstract Background The Ehlers-Danlos syndromes (EDS) are rare connective tissue disorders consisting of 13 subtypes with overlapping features including joint hypermobility, skin and generalized connective tissue fragility.Classical EDS (cEDS) is principally caused by heterozygous COL5A1 or COL5A2 variants and rarely by the COL1A1 p.(Arg312Cys) sub

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A metabolic checkpoint protein GlmR is important for diverting carbon into peptidoglycan biosynthesis in Bacillus subtilis.

The Bacillus subtilis GlmR (formerly YvcK) protein is essential for growth on gluconeogenic carbon sources.Mutants lacking GlmR display a variety of phenotypes suggestive of impaired cell wall synthesis including antibiotic sensitivity, Bain Marie Thermostat aberrant cell morphology and lysis.To define the role of GlmR, we selected suppressor mutat

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Slug Monitoring and Impacts on the Ground Beetle Community in the Frame of Sustainable Pest Control in Conventional and Conservation Agroecosystems

In conservation agriculture, slugs are considered significant pests and their monitoring is a key option in the integrated pest management framework.Together with molluscicide applications, predators such as ground beetles can offer a tool for slug control in the field.Through the evaluation of slug and ground beetle monitoring strategies, this wor

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